The Incredible Hulk is the second movie made in the Marvel Cinematic Universe. It is the story of Bruce Banner becoming The Hulk.
Dr. Bruce Banner, thanks to a gamma ray experiment gone wrong, transforms into a giant green-skinned hulk whenever his pulse gets too high. Meanwhile, a soldier uses the same technology to become an evil version of the original.
A series of flashback shots show the gamma radiation accident that transformed scientist Bruce Banner into the the Hulk, and hospitalized his lover Betty Ross. Now a fugitive from the United States Army, and Betty's father, General Thaddeus Ross, Banner goes on the run for five years. He settles in Brazil, working in a soft drink bottling factory while attempting to find a cure for his condition with the help of an Internet friend, "Mr. Blue". He also studies martial arts and meditative breathing techniques with a Brazilian Jujitsu expert to help control his emotions, and has not suffered a transformation for five months.
After Banner suffers a cut, and his blood drips into a soda bottle eventually drank by an ill-fated consumer in Milwaukee, Wisconsin, Ross discovers Banner's location, and sends a team to capture him, led by Russian-born British special operations expert Emil Blonsky. Following a ferocious battle in the soft drink bottling plant where he transforms into the Hulk, Banner escapes Blonsky, and ends up in Guatemala. He travels to the United States, where he sees that a now-recovered Betty is working at Culver University and is dating psychiatrist Leonard Samson. He also sees his old friend Stanley, a pizzeria owner, who gives him a job as a delivery boy. Banner uses this job to sneak past a security guard to continue his research. After Betty visits the pizzeria and sees Bruce, she later reunites with him.
Blonsky reports to Ross that Banner evaded them in Brazil because of the appearance of a large green monster. Ross explains that the monster is Banner, and that he was created accidentally during an experiment in radiation-resistance that was inspired by World War II era military bio-force enhancement research (or "Super-Soldiers", as Blonsky puts it). Blonsky, seeking both revenge and power, volunteers as a test subject in order to capture Banner. He receives a small dose of the mothballed original Vita Ray serum, created by Dr. Reinstein for Weapon Plus. He leads an assault on Banner at Culver University, during which Betty is knocked unconscious. Despite Blonsky's increased strength, speed and agility, the Hulk crushes most of the bones in Blonsky's body. The Hulk saves Betty from an explosion and escapes with her to the Smoky Mountain National Forest.
Banner and Betty then travel to Empire State University in New York City, where they meet "Mr. Blue", Samuel Sterns. Accompanying Sterns to his lab, Banner and Betty learn that Sterns has developed a possible antidote that may cure Banner's condition or merely reverse each individual transformation while an overdose could kill him. Despite the risks, Banner agrees to test Sterns' antidote and is restrained before being shocked into transforming with electricity before being reverted to normal with an injection of the serum. Exhilarated by the success of the antidote, Sterns reveals that he has synthesized Banner's blood sample into a large supply with the intention of using it to enhance the human condition to the next evolutionary level. Appalled by what Sterns had done and fearful of the Hulk's power falling into the wrong hands, Banner attempts to convince Sterns to destroy the blood supply but is shot by a tranquillizer from one of General Ross' snipers.
As both Banner and Betty are taken into custody, Blonsky, whose super-soldier treatment has healed all his injuries but is desperate for more power, demands Sterns subject him to a dose of the Banner's gamma radiation treatment. Sterns warns that the combination of the Super Soldier formula and a gamma treatment would be an unpredictable combination that could turn him into an "abomination". Blonsky is less than concerned about this, and Sterns promptly administers the gamma charge. As Blonsky mutates into the monstrous Abomination, he knocks Sterns aside and an irradiated sample of Banner's blood-derivative drips into an open wound on Sterns's temple, causing his cranium to mutate and expand. In an attempt to draw the Hulk out, the Abomination goes on a rampage through Harlem and Banner, realizing that he is the only one who can stop the Abomination, convinces General Ross to release him. He jumps out of Ross' helicopter as it hovers over the city, hoping the fall will stimulate his adrenal glands into triggering a transformation. Banner's plan succeeds and after a brutal battle the Hulk manages to defeat the Abomination by strangling him with a huge chain, though he releases his grip after a plea from Betty. The Abomination collapses, and the Hulk flees the scene with the army in hot pursuit.
Thirty-one days later, Banner is in Bella Coola, British Columbia. Instead of trying to suppress his transformations, he is attempting to initiate them in a controlled manner. As his eyes turn green, a grin appears on his face.
- Nick Fury's name is seen in the intro.
- Stark Industries logo is also seen in the intro showing they created the Sonic Cannons used later and it is also on the Cyrosync container containing the Super Soldier Serum.
- The S.H.I.E.L.D. logo is seen in the intro, it's again seen when Bruce Banner uses a computer.
- General Ross talks about a program in World War 2 to create Super Soldiers with the Super Soldier Serum which is obviously refering to the creation of Captain America.
- When General Ross first takes the Super Soldier Serum out of its Cyrosync container, the label on the container says it was developed by Dr. Reinstein, the alias of Abraham Erskine. The label also says the program was called Weapons Plus.
- When General Ross is sitting in a bar, Tony Stark appears and talks to him about The Avengers.