Iron Man 2: Defeat The Enemy is the sequel to Iron Man and is the third movie made in the Marvel Cinematic Universe.
With the world now aware of his identity as Iron Man, Tony Stark must contend with both his declining health and a vengeful mad man with ties to his father's legacy.
As Tony Stark reveals to the world that he is Iron Man, in Russia Anton Vanko died after telling his son Ivan to use what he had been taught. Six months later, Stark has used his Iron Man armor to bring about a negotiated peace between the major super powers of the world, and his immense popularity with the general public is only furthered when he fulfills his father's dream by opening the "Stark Expo", to showcase all the latest inventions that will benefit the world. Stark is, however, still vilified by the United States government, and Senator Stern in particular, who demands that he hand his armor technology over for military application. Stark refuses, publicly shaming rival Justin Hammer in the process by highlighting his own failed attempts at recreating the technology. All is not well in Stark's life, however: he has discovered that the Palladium in the arc reactor keeping his heart beating has begun to poison his body, slowly killing him, and all attempts to find a substitute element have failed. Slowly going off the rails as a consequence of what he believes to be his impending death, he appoints his former personal assistant Pepper Potts CEO of Stark Industries, replacing her with Natalie Rushman.
While racing in Monaco, Stark is attacked by Ivan Vanko, who has constructed a miniaturized arc reactor of his own, including whip-like attachments harnessing the electrical energy. Defeating Vanko with the aid of his MK V Suit (a transforming briefcase), Stark discovers that Vanko is the son of disgraced Russian physicist Anton Vanko, who collaborated on the first arc reactor with Stark's father Howard. Vanko is promptly broken out of jail by a revenge-seeking Justin Hammer, who puts him to work fashioning a line of battle droids that he will use to upstage Stark at his own Expo.
Tony throws what he believes will be his last birthday party and promptly proceeds to get drunk whilst wearing the Iron Man armor, forcing his friend, Lt. Colonel James Rhodes to don the MK II Suit and subdue him. Disgraced, Stark is approached by Nick Fury of S.H.I.E.L.D., who provides him with a chest of his father's old artifacts that can hopefully be used to find a cure for his palladium poisoning. Reviewing the film reels in the chest, Stark discovers a message from his father that leads him to the original 1974 diorama of the Stark Expo: in reality, a disguised diagram for the molecular structure of a new element. Stark hand-builds a particle accelerator with the aid of his computer J.A.R.V.I.S and synthesizes this new element, creating a new triangular chest arc that cures his poisoning.
Simultaneously, at Stark Expo, Hammer unveils his new military drones, captained by Rhodes in a heavily-weaponised version of the confiscated Mark II armor (War Machine Suit). Unfortunately, it is soon discovered that Vanko has complete control of both the drones and Rhodes's new armor, and Stark arrives just as they go on the attack. As Stark battles against these remote-controlled enemies, Happy Hogan and Natalie (an undercover S.H.I.E.L.D. agent named Natalia Romanoff) race to Hammer's Queens facility to stop Vanko. By the time they arrive, Vanko has already departed for the Expo in a new, more powerful suit of armor, but Natalie is able to give Rhodes control of his armor again so that he and Stark can fight Vanko together. The two armored allies combine their powers and successfully take Vanko down, but his armor and Hammer's Drones are revealed to have been equipped with self-destruct charges. As they begin to go off, Stark races to save Pepper, rescuing her at the last minute. She quits her CEO position, and she finally gives Tony a kiss.
At a debriefing, Fury informs Stark that while Stark is "unsuitable" for the Avengers Initiative, S.H.I.E.L.D. wants Iron Man as a consultant. Stark agrees on the condition that Senator Stern present him and Col. Rhodes with their medals for bravery.
Agent Coulson is seen driving to a remote impact crater in the New Mexico desert. Over a phone, he informs Fury that they've "found it". The camera then pans from the opposite side's view and Thor's Hammer is seen and thunder is heard as the screen fades to black.
- Robert Downey Jr. - Tony Stark
- Don Cheadle - James Rhodes
- Mickey Rourke - Ivan Vanko
- Gwyneth Paltrow - Virginia 'Pepper' Potts
- Sam Rockwell - Justin Hammer
- Paul Bettany - the voice of J.A.R.V.I.S
- Samuel L. Jackson - Nick Fury
- Scarlett Johansson - Natasha Romanoff
- Clark Gregg - Phil Coulson
- Jon Favreau - Happy Hogan
- John Slattery - Howard Stark
- As Nick Fury debriefs Tony near the end of the film, the television screen on the right shows a news report of a destructive aftermath on a university campus. This is the same news report of the Culver University battle caused by the Hulk that was featured midway in the film The Incredible Hulk, indicating that the last moments of Iron Man 2: Defeat The Enemy is concurrent with the events of the latter film.
- On the other maps you can see points that are related to Hulk, Thor and Captain America confirmed by Jon Favreau.
- When Phil Coulson was looking around Tony's workshop he finds a familiar incompleted sheild in a crate. It's heavily hinted to be either Captain America's actual shield or a prototype of it. It was previously featured midway in Iron Man.
- The new element Tony creates is the metal The Tesseract is composed of, which is studied by Howard Stark in Captain America: Secret Agency.
- In New Mexico, Phil Coulson finds Mjolnir, the weapon used by Thor, in a crater.
- Nick Fury mentions problems in the southwest region which is where Mjolnir was lying.
- Tony Stark looks at a folder and has Avengers Initiative printed on it, again a reference to his upcoming participation with the Avengers.